Genetic variation: effect on prostate cancer

Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.

BACKGROUND Only a minority of the genetic components of prostate cancer risk have been explained. Some observed associations of SNPs with prostate cancer might arise from associations of these SNPs with circulating prostate-specific antigen (PSA) because PSA values are used to select controls. METHODS We undertook a genome-wide association study (GWAS) of screen-detected prostate cancer (Prot...

association studies cancer and the effect of control selection on genetic Genetic variation in protein specific antigen detected prostate

MIC1 and IL1RN genetic variation and advanced prostate cancer risk.

Recently, polymorphisms in macrophage inhibitory cytokine-1 (MIC1) and interleukin 1 receptor antagonist (IL1RN) were identified to be associated with prostate cancer risk (1-3). MIC-1 is a divergent member of the transforming growth factor-h superfamily of cytokines. In the Cancer Prostate in Sweden study, the nonsynonymous MIC1 H6D polymorphism was associated with a lowered risk of prostate c...

Genetic characteristics of prostate cancer.

Prostate cancer is the most commonly diagnosed malignancy in united States males. Unfortunately, numerous controversies surround clinical management for early stage disease and the utility of population screening. Much of this controversy stems from the lack of knowledge about the biology of prostate cancer, including the lack of clearly defined risk factors, absence of markers indicative of ag...

Genetic Epidemiology of Prostate Cancer

.........................................................................................................................6 Original papers ..............................................................................................................7 Abrevations....................................................................................................................8 Introduction .......